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Acid Alfa Lipoic este un puternic antioxidant de 40-60 ori ca Vitamina E, regenereaza antioxidanti.
| Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina | Reversia fenotipului malign prin inhibarea celulelor de cancer |
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Neutralizarea de radicali liberi - Densitatea antioxidativa
Despre antioxidanti: Antioxidantii sint molecule care apara
organismul de efectele oxigenului reactiv - Radicalii liberi
Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula de radicalii
liberi care sint molecule instabile, contin electroni neimperecheati, adica
un electron ocupa un singur orbital.
Disfunctia mitocondriala care este o caracteristica a celulelor
maligne, datorat prin capacitatea scazuta antioxidativa.
| Antioxidantii apara celula de efectele oxigenului reactiv | Antioxidantii cu neutralizarea de radicali liberi - Capacitate scazuta antioxidativa |
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Antioxidanti se gasesc in orice celula, protejeaza organismul
de distrugerile provocate la nivel celular de radicalii liberi.
Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata,
daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa
Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti
ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa
de efectele radicalilor liberi.
Antioxidantii protejind celula de radicalii liberi
- Capacitate suficienta
Sint o multime de antioxidanti in extracte de plante naturale,
fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor
liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine:
Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten,
licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli
care confera protectie ridicata antoxidativa
Suficienti antioxidanti
de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina
C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime
antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul
superoxid, peroxidul de hidrogen (H 2O2) si Glutation
peroxidaza (GPx) care detoxifica peroxizii celulari
Spirulina contine
superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g
Suficienti antioxidanti de recomandat: Acid alfa
lipoic, Ceai Verde, Vitamina C, Glutation, Vitamin E, Carotenoizi,
Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza
(SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H2O2)
si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari
EGCG cu capacitate de absorbtie a radicalului liber
a oxigenului - ORAC, comparatia valorilor fata de Vitamina C
Acidul Alfa
Lipoic regenereaza antioxidanti ca: Glutationul oxidat la glutation
redus, Coenzima Q10, Vitamina C, Vitamina E, Glutationul disulfid, Cistina
in Cisteina, Tioredoxina oxidata la Tioredoxina redusa importanta care
leaga factori de transcriptie de ADN
12 Acid Alfa Lipoic cu actiunea
de regenerare a altor antioxidanti Vitamina
C (acidul
dehidroascorbic forma oxidata) etc.
13 Mitocondria reduce Acid Alfa Lipoic prin enzima lipo amida dehidrogenaza in
Acid Dihidro lipoic
(ADHL)
Mitocondria reduce Acid Alfa Lipoic prin
enzima lipoamida dehidrogenaza in Acid Dihidro lipoic
(ADHL)
14 Acid
Alfa Lipoic previne oxidarea de LDL colesterol implicat in bolile de inima
si ateroscleroza
15 Acid
Alfa Lipoic reduce rectiile de glicozilare la diabetul
zaharat tip
2 - 2,2 Milioane de oameni mor anual datorita cauzei nivelului ridicat de glucoza
la diabetul zaharat,
dupa concluzia la Harvard School of Public Health din Boston in 52 de tari.
Oamenii de stiinta: Goodzard Denaei si Majid Ezzati accentueaza ca
nivelul ridicat de glucoza in singe apar complicatii
la nivelul ochilor,
inimii, vaselor de sange, nervilor si rinichilor
Ce nu va relateaza medicul despre diabet: Hemoglobina glicozilata
- (HbA1c) de 5% este valoarea optimala pentru controlul
metabolic si a logevitatii este reducerea glucozei la nivelul de 70
- 80 mg/dl
Dar pentru managementul zilnic cu Self-monitoring Blood Glucose Profile (SMBG)
pentru ajustarea terapiei respectiv de Hemoglobina glicozilata - hemoglobina
A1c la 5% - 70 - 80 mg/dl valoarea optimala
Masurarea de Hemoglobina glicozilata - hemoglobina A1c nu este limitata fata
de variabilitatii glicemice
Hemoglobina A1c nu diferentiaza glicemia de fasting - post, prandiala,
si postprandiala
16 Substante nutritive cu actiune de anti-glicozilare sint: Carnosina si
Acid Alfa Lipoic.
Acid Alfa Lipoic reduce nivelul ridicat de glucoza la diabetul zaharat
- Zahar
16 Acid
Alfa Lipoic cu efect
benefic la pacienti de diabet zaharat tip
2
Tratamentul la diabet zaharat tip 2 pentru reducerea de glicemie: Crom
la formula Super Citrimax(R) fibra
dietetica la formula Super Chitosan
Plus sau Set Cura de Slabire important pentru reglarea de glicemie
Glicemie - Diabetul zaharat: Aparate de masurat glicemia - glucometru
- nutitie - Index
Glicemic - Suplimente Nutritionaale - Set
Cura de Slabire
Trusa glucometru: Aparat pentru determinarea de glicemie cu trusa prim ajutor
la hipoglicemie, monitorizarea glicemiei
Daca glicemia persista la un nivel crescut: Hiperglicemie apar complicatii
la nivelul ochilor,
inimii, vaselor de sange, nervilor si rinichilor
17 Acid
Alfa Lipoic indicat in tratamentul de neuropatie diabetica-polineuropatie
diabetica, studiu randomizat, dublu-orb, placebo controlat.
18 Acid
Alfa Lipoic creste numarul de anticorpi este imunomodulator
19 Acid
Alfa Lipoic cu actiunea sa antioxidanta previne, ajuta la bolile ochilor
20 Acid
Alfa Lipoic este un Anti Aging are actiune neuroprotectiva previne bolile
degenerative, intirzie
inbatrinirea
| Dr.
MD. Roy L. Waldford, Lisa Waldford - The Anti Aging Plan: Strategies and Recipes for Extending Your Healthy Years |
 Crono
Forte - Formula Anti Aging3 Capsule contine: |
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|
Mod
de administrare:
Anti-Aging-Systeme
- Formula
AntiAging
Bibliografie - Referinte Acid Afa Lipoic
Informatii din bibliografia electronica la tema: Nutritie si sanatate
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2. Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. (R)-alpha-lipoic acid-supplemented
old rats have improved mitochondrial function, decreased oxidative damage,
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Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew
JC, Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly
improves metabolic function while decreasing oxidative stress. Department of
Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University,
Corvallis, OR 97331, USA. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5.
3. The
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MD, Khan MJ, Bai U, Shirwany N, Quirk WS. Biologic activity of mitochondrial
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TM, Moreau R, et al: Mitochondrial decay in the aging rat heart: evidence for
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G, Beikler TK, Schneider M, et al. Dose/response curves of lipoic acid R- and
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MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha
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C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella
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H, Murphy ME, Sies H. Antioxidant activity of dihydrolipoate against
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Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated
by tocopherol recycling. Biochem
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B, et al. Influence of alpha-lipoic acid on intracellular glutathione in
vitro and in vivo. Arzneimittelforschung1992;42:829–31.
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of lipoic acid by lipoamide dehydrogenase. Biewenga GP, Dorstijn MA, et
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14. Nichols
TW Jr. Alpha-lipoic acid: biological effects and clinical implications. Altern
Med Rev 1997;2:177–83
15. Jacob
S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI,
Augustin HJ, Dietze GJ. Enhancement of glucose disposal in patients with
type 2 diabetes by alpha-lipoic acid. Department of Internal Medicine, City
Hospital, Baden-Baden, Germany. Arzneimittelforschung. 1995 Aug;45(8):872-4.
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Mode of action of lipoic acid in diabetes. J Biosci. 1987; 11:59-74.
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Hokama JY Tritschler HJ Dietze GJ Henriksen EJ, The antioxidant alpha-lipoic
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J. The AGE of the matrix: chemistry, consequence and cure. Director of Matrix
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17. Heitzer
T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T. Beneficial effects
of alpha-lipoic acid and ascorbic
acid on endothelium-dependent, nitric
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of oxidative stress. Universitatsklinikum Hamburg-Eppendorf Klinik und Poliklinik
fur Innere
Medizin, Abteilung Kardiologie, Hamburg, Germany. heitzer@uke.uni-hamburg.de.
Free Radic Biol Med. 2001 Jul 1;31(1):53-61.
18. Nickander
KK, McPhee BR, Low PA, Tritschler H. Alpha-lipoic acid: antioxidant potency
against lipid peroxidation of neural tissues in vitro and implications
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throctic acid in the therapy of peripheral diabetic neuropathy. Horm Metab
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Improves Pain, Nerve Regeneration, and Vibratory Perception in Patients With
Chronic
Diabetic Neuropathy: An analysis of two randomized placebo-controlled trials.
Department
of Pathology, Wayne State University School of Medicine, 540 E. Canfield
Ave., Detroit, MI 48201. asima@med.wayne.edu. Diabetes Care. 2005 Jan;28(1):89-94.
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KJ, Meissner HP, Lobisch M, Schutte K, Gries FA. Treatment of symptomatic
diabetic peripheral neuropathy
with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized
controlled
trial (ALADIN Study). Diabetes-Forschungsinstitut an der Heinrich-Heine-Universitat,
Dusseldorf, Germany. Diabetologia. 1995 Dec;38(12):1425-33.
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Conrad, F. A. Gries, H. Ulrich and G. Reichel (1997). "Effects of treatment with the antioxidant alpha-lipoic
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KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R. Treatment of symptomatic
diabetic polyneuropathy
with
the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled
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Dusseldorf, Germany. dan.ziegler@dfi.uni-duesseldorf.de. Diabetes Care.
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J. R. Finn, M. Reljanovic, M. Lobisch, K. Schutte, D. Nehrdich, H. J. Tritschler,
H. Mehnert and D.
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K, Lobisch M, Schuette K, Moller W, Tritschler HJ, Mehnert H. Treatment
of diabetic polyneuropathy
with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter
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for Diabetes, Endocrinology and Metabolic Diseases Vuk Vrhovac, Medical
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19. Ohmori
H, Yamauchi T, Yamamoto I. Augmentation of the antibody response by lipoic
acid in mice II. Restoration of the antibody response in immunosuppressed
mice. Japan J Pharmacol 1986; 42:275-280.
20. Filina
AA, Davydova NG, Endrikhovskii SN, Shamshinova AM. Lipoic acid as a means
of metabolic therapy of open-angle glaucoma. Vestn Oftalmol. 1995 Oct-Dec;111(4):6-8.
21. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant
alpha-lipoic acid. Free Rad Biol Med. 1997; 22:359-378.
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Neuroprotective effects of alpha-lipoic acid and its positively charged amide
analogue. Free Rad
Biol Med. 1999; 26:1418-1426.
Literatura
- Packer L, Colman C: The Antioxidant Miracle. John Wiley & Sons, New York 1999.
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