Fountain
of Youth Anti-Aging
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Antioxidant,
antioxidanti: Antioxidantii fantana tineretii
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1. Teoria radicalilor liberi in procesul de imbatrinire
| Formarea de radicali liberi | Structura celulei este oxidata de actiunea agresiva a radicalilor liberi |
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2. Ginkgo Biloba extract din folium sicc. (Ginkgo extract) un inhibitor de stresul oxidativ care induce agregarea plachetara
| Radicalii liberi produc stres oxidativ | Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ |
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| Degradarea ADN-ului prin acumularea de 8-hidroxi-2’-deoxiguanozina | Reversia fenotipului malign prin inhibarea celulelor de cancer |
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Neutralizarea de radicali liberi - Densitatea antioxidativa
3. Ginkgo Biloba un natural antioxidant neutralizeaza radicalii liberi si efect de protectie de dauna oxidativa a ADN
| Antioxidantii apara celula de efectele oxigenului reactiv | Antioxidantii neutralizeaza radicalii liberi - Capacitate scazuta antioxidativa |
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Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta

- Spirulina contine superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g
| Coenzima Q10 cu activitate in mitocondrii: Mitocondria uzina energetica de adenozintrifosfat (ATP) a materiei vii, activeaza producerea de adenozintrifosfat (ATP) |
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| Creier sanatos | Creier cu Alzheimer |
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Ceai Verde (Camellia Sinensis) - foto
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| EGCG un produs natural fotoprotector protejaza pielea |
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| EGCG cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C |
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| Quercitina cu: Flavonoizi, Polifenoli 95% din: Farmacia Naturala |
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Quercetin cu activitate: antioxidanta, anti-inflammatorie, antivrala, immunomodulatoare, anti cancer, gastroprotectiva, anti alergica si in prevenirea de complicatii ale diabetului.
| Quercetina cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C |
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| Extract din Samburi de Struguri (Vitis Vinifera) OPC extr. stand. 95% |
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| OPC 95% cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C |
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24. Capsaicina cu activitate antioxidanta
| Capsaicina cu activitate antioxidanta |
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| N-Acetilcisteina efect protector la plamin |
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| N-Acetilcisteina cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C |
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- Acid Alfa Lipoic (AAL) este un di-sulfid, numit si acid tioctic sau lipoate poate regenera antioxidanti ca: Glutationul oxidat la glutation redus, Coenzima Q10, Vitamina C, Vitamina E, Glutationul disulfid, Cistina in Cisteina, Tioredoxina oxidata la Tioredoxina redusa importanta care leaga factori de transcriptie de ADN.
| Actiunea acidului alfa lipoic regenereaza alti antioxidanti ca: Coenzima Q10, |
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| Vitamina C, Glutation, Vitamina E |
31. Acid Alfa Lipoic cu efect biologic si implicatii clinice
| Resveratrol un antioxidant natural cu cu eficienta de actiune in oxidarea in lipozom |
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| Bibliografie-Referinte: |
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| Informatii din bibliografia electronica la tema: Nutritie si sanatate |
1. Beckman, K. & Ames, B. (1998) "The free radical theory of aging matures" Physiol Rev 78: 548-81.
2. Akiba S, Kawauchi T, Oka T, Hashizume T, Sato T.Inhibitory effect of the
leaf extract of
Ginkgo biloba L. on oxidative stress-induced platelet aggregation.Department
of Pathological Biochemistry, Kyoto Pharmaceutical University, Japan.Biochem
Mol Biol Int. 1998
Dec;46(6):1243-8.
3. Haramaki N, Aggarwal S, Kawabata T, Droy-Lefaix MT, Packer L.Effects
of natural antioxidant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion
injury. Department of Molecular and Cell Biology, University of California, Berkeley
94720.Free Radic Biol Med. 1994 Jun;16(6):789-94.
4. Bekerecioglu M, Tercan M, Ozyazgan I.The effect of Gingko
biloba extract (Egb 761) as a free radical scavenger on the survival of skin
flaps in rats. A comparative study. Department of Plastic and Reconstructive
Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.Scand J Plast
Reconstr Surg Hand Surg.
1998 Jun;32(2):135-9.
5. Ernster L. (1977) Facts and ideas
about the function of coenzyme Q10 in the Mitochondria. In: Folkers K., Yamamura
Y.
(eds) Biomedical and Clinical Aspects of Coenzyme Q. Elsevier, Amsterdam, pp
15-8.
6. Ernster L., and Forsmark P Ubiquinol
: an endogenous antioxidant in aerobic organisms. Seventh International Symposium on Biomedical and Clinical Aspects of Coenzyme
Q10 Folkers K., et al (Eds) The
Clin Inves 1993 ; Suppl 71 (8): S60-S65.
- Aryoma O. Free Radicals And Antioxidant strategies in sports.J Nutr Biochem
1994 5:370
- Lockwood K., Moesgaard S., Hanioka T., Folkers K. Apparent partial remission
of breast cancer in high risk patients supplemented with nutritional antioxidants,
essential fatty acids and coenzyme Q10. Mol Aspects Med 1994;15
Suppl:s231-40.
- Ingold K.U., Bowry V.W., Stocker R.Autoxidation
of lipids and antioxidation by
alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences
of lipid particle size as exemplified by oxidation of human low density lipoprotein.
Proc Natl Acad Sci U SA 1993 Jan
1;90(1):45-9.
- Lass A, Sohal RS. Effect of coenzyme Q10 and alpha-tocopherol content of mitochondria
on the production of superoxide anion radicals. FASEB J. 2000; 14:87-94.
- Tomasetti M, Littaru GP, Stocker R, Alleva R. Coenzyme Q10 enrichment decreases
oxidative DNA damage in human lymphocytes. Free Rad Biol Med. 1999; 27:1027-1032.
7. Beal MF. Mitochondrial
dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and
coenzyme Q10 as a potential treatment. Department of Neurology and Neuroscience,
New York Presbyterian Hospital-Weill Medical College of Cornell University, 525
East 68th Street, New York, New York 10021, USA. fbeal@med.cornell.edu J Bioenerg
Biomembr. 2004 Aug;36(4):381-6.
- Beal MF. Mitochondria, oxidative damage, and inflammation in Parkinson's disease.
Department of Neurology and Neuroscience, Weill Medical College of Cornell University,
New York Presbyterian Hospital, New York, New York 10021, USA. fbeal@med.cornell.edu
Ann N Y Acad Sci. 2003 Jun;991:120-31.
8. Mazur
WM, Wahala K, Rasku S, Salakka A, Hase T, Adlercreutz
H. Lignan and isoflavonoid concentrations in tea. Department of Clinical
Chemistry, University of Helsinki, Finland. Br J Nutr. 1998 Jan;79(1):37-45.
- Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on
cardiovascular and liver diseases. British Medical Journal, 1995;
310: 693-696.
9. Shigenaga MK, Ames BN. Assays
for 8-hydroxy-2'-deoxyguanosine, a biomarker of in vivo oxidative DNA
damage. Free
Radic. Biol. Med., 1991;
10: 211-6.
- H. Kasai, P.F. Crain, Y. Kuchino, S. Nishimura, A.Ootsuyama and H. Tanooka.
Carcinogenesis 7:1849-51, 1986.
10. Katiyar SK. Skin
photoprotection by green tea: antioxidant and immunomodulatory
effects. Department of Dermatology, University of Alabama at
Birmingham, Birmingham, AL 35294, USA. Curr Drug Targets Immune
Endocr Metabol Disord. 2003 Sep;3(3):234-42.
- H. Ochi. Rouka seigyo syokuhin no kaihatsu (Development of foods for control
of aging)
Korin Press,
p. 294, 1995.
11. Chyu KY, Babbidge SM, Zhao X, Dandillaya
R, Rietveld AG, Yano J, Dimayuga P, Cercek B, Shah PK. Differential effects of
green tea-derived catechin on developing versus established atherosclerosis in
apolipoprotein E-null mice. Atherosclerosis Research Center, Division of Cardiology,
and Department of Medicine, Cedars-Sinai Medical Center and David Geffen School
of Medicine at the University of California, Los Angeles, CA 90048, USA.Circulation.
2004 May 25;109(20):2448-53. Epub 2004 May 10
- Peters U, Poole C, Arab L. Does tea affect cardiovascular disease A meta-analysis.
Am J Epidemiol. 2001;154(6):495-503.
12. Crouvezier, S., Powell,
B., Keir, D., and Yaqoob, P. (2001) The effects of phenolic components
of tea on the production
of pro- and anti-inflammatory cytokines by human leukocytes in
vitro. Cytokine 13, 280-286.
13. Khalfoun B, et al., Docosahexaenoic
and eicosapentaenoic acids inhibit in vitro human endothelial cell production
of interleukin-6. Adv Exp Med Biol 1997;400B:589-97
- Terano T, et al. Eicosapentaenoic acid as a modulator of inflammation. Effect
on prostaglandin and leukotriene synthesis. Biochem Pharmacol 1986 Mar 1;35(5):779-85
-R aederstorff D, et al. Anti-inflammatory properties of docosahexaenoic and
eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. Int Arch
Allergy Immunol 1996 Nov;111(3):284-90
- Mayatepek E, et al. Influence of dietary (n-3)-polyunsaturated fatty acids
on leukotriene B4 and prostaglandin E2 synthesis and course of experimental tuberculosis
in guinea pigs. Infection 1994 Mar-Apr;22(2):106-12
- Khalfoun B, et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro
human lymphocyte-endothelial cell adhesion. Transplantation 1996 Dec 15;62(11):1649-57
14. Morand C, Crespy V, Manach C, Besson
C, Demigne C, Remesy C. Plasma
metabolites
of quercetin and their antioxidant properties. Laboratoire des Maladies Metaboliques
et des Micronutriments, Institut National de la Recherche Agronomique de Clermont-Ferrand/Theix,
63122 Saint-Genes-Champanelle,
France.
- Hollman PC, van Trijp JM, Mengelers MJ, de Vries JH, Katan MB. Bioavailability
of the dietary antioxidant flavonol quercetin in man. DLO State Institute for
Quality Control of Agricultural Products (RIKLIT-DLO), Wageningen, The Netherlands.
p.c.h.hollman@rikilt.dlo.nl Cancer Lett. 1997 Mar 19;114(1-2):139-40.
15. Bindoli A, Valente M, Cavallini L. Inhibitory
action of quercetin on xanthine
oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun. 1985 Sep;17(9):831-9.
16. Wiseman H, O'Reilly J. Influence
of the dietary flavonoid quercetin on the cardioprotective antioxidant action
of oestrogen and phytoestrogens. Biochem Soc Trans. 1997 Feb;25(1):108S.
17. Afanas'ev IB, Dorozhko AI, Brodskii
AV, Kostyuk VA, Potapovitch AI. Chelating
and free radical scavenging mechanisms of inhibitory action of rutin and
quercetin in lipid peroxidation. All-Union Vitamin Research Institute,
Moscow, U.S.S.R. Biochem Pharmacol. 1989 Jun 1;38(11):1763-9.
18. Terao J. Dietary flavonoids as
antioxidants in vivo: conjugated metabolites of (-)-epicatechin and quercetin
participate
in antioxidative defense in blood
plasma. J Med Invest. 1999 Aug;46(3-4):159-68.
19. Heo HJ, Lee CY. Protective
effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration.
Department of Food Science and Technology, Cornell University, Geneva, NY 14456,
USA.
J Agric Food Chem. 2004 Dec 15;52(25):7514-7.
20. Schwitters B, et al. OPC in practice.
Bioflavanols and their applications. Rome, Italy: Alfa Omega, 1993.
- Masquelier J. Procyanidolic oligomers. J Parums Cosm Arom 95: 89–97,
1990.
21. Yu YM, Chang WC, Wu CH, Chiang SY. Reduction of oxidative stress
and apoptosis in hyperlipidemic rabbits by ellagic acid. Department of
Nutrition, China
Medical University, Taichung, Taiwan. yuyamei@hotmail.com J Nutr
Biochem. 2005 Nov;16(11):675-81.
Epub 2005 Aug 2.
22. Majid S, Khanduja KL, Gandhi RK, Kapur S, Sharma RR. Influence of
ellagic acid on antioxidant defense system and lipid peroxidation in mice. Department
of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh,
India. Biochem Pharmacol. 1991 Sep 12;42(7):1441-5.
- Osawa, T., Ide, A., Su, J. D., and Namiki, M., Inhibition of lipid peroxidation
by ellagic acid. J. Agric. Food Chem., 35, 808–812
- Ashoori F, Suzuki S, Zhou JH, Isshiki N, Miyachi Y. Involvement of lipid peroxidation
in necrosis of skin flaps and its suppression by ellagic acid. Department of
Plastic and Reconstructive Surgery, Kyoto University Hospital, Japan. Plast Reconstr
Surg. 1994 Dec;94(7):1027-37.
23. Pavlica S, Gebhardt R. Protective effects of ellagic and chlorogenic acids
against oxidative stress in PC12 cells. Institut fur Biochemie, Medizinische
Fakultat, Universitat Leipzig, Liebigstr. 16, Leipzig, 04103, Germany. Free Radic
Res. 2005 Dec;39(12):1377-90.
24. Ochi T, Takaishi Y, Kogure K, Yamauti I.Antioxidant activity
of a new capsaicin derivative from Capsicum annuum. J Nat Prod.
2003 Aug;66(8):1094-6.
25. Ortolani O, Conti A, De Gaudio AR, et al. Protective effects
of N-acetylcysteine and rutin on the lipid peroxidation of the
lung epithelium during the adult respiratory
distress syndrome. Shock. 2000; 13:14-18.
- Sala R, Moriggi E, Corvasce G, Morelli D. Protection by N-acetylcysteine against
pulmonary endothelial cell damage induced by oxidant damage. Eur Respir J. 1993;
6:440-446.
26. Bongers V, de Jong J, Steen I,
et al. Antioxidant-related parameters in patients treated for cancer chemoprevention
with N-acetylcysteine. Europ J Cancer. 1995;
31A:921-923.
- Oikawa S, Yamada K, Yamashita N, et al. N-acetylcysteine, a cancer chemopreventive
agent, causes oxidative damage to cellular and isolated DNA. Carcinogenesis.
1999; 20:1485-1490.
27. Aruoma OI, Halliwell B, Hoey
BM, Butler B: The antioxidant action of N-acetylcysteine; its reaction
with hydrogen
peroxide, hydroxyl radical, superoxide, and hypochlorous
acid. J Free Radic Biol Med 1989, 6:593-597.
28. Packer L, Witt EH, Tritschler, HJ. Alpha-lipoic as a biological antioxidant.
Free Rad Biol Med. 1995; 19:227-250.
- Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic
and concentration, recycling and biosynthesis in rat hepatocytes-reversal with
(R)-alpha-lipoic acid supplementation. FASEB J. 1998; 12:1183-1189.
29. Dietrich,
M., G. Block, M. Hudes, J. D. Morrow, E. P. Norkus, M. G. Traber, C. E. Cross
and L. Packer (2002). "Antioxidant
supplementation decreases lipid peroxidation biomarker F(2)- isoprostanes in
plasma of smokers." Cancer Epidemiol Biomarkers Prev 11(1): 7-13.
- Calabrese V, Ravagna A, Colombrita
C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM.
Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against
oxidative stress: Involvement of the transcription factor Nrf2. Department
of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine,
University of Catania, Catania, Italy. J Neurosci Res. 2005 Jan 7.
- Marangon K, Devaraj S, Tirosh O, et
al. Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation
on measures of oxidative stress. Free Rad Biol Med. 1999; 27:1114-1121.
- Kagan V, Khan S, Swanson C, et al.
Antioxidant action of thioctic acid and dihydrolipoic acid. Free Radic Biol
Med 1990;9S:15.
- Martin E, Rosenthal RE, Fiskum G.
Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and
target of oxidative stress. Department of Anesthesiology, University of Maryland
School of Medicine, Baltimore, Maryland. J Neurosci Res. 2005 Jan 1;79(1-2):240-7.
31. Scholich H, Murphy ME, Sies
H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation
and its dependence
on alpha-tocopherol. Biochem
Biophys Acta 1989;1001:256–61.
- Kagan V, Serbinova E, Packer L. Antioxidant
effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol
recycling. Biochem Biophys Res Commun 1990;169:851–7.
- Busse E, Zimmer G, Schorpohl B, et
al. Influence of alpha-lipoic acid on intracellular glutathione in vitro and
in vivo. Arzneimittelforschung1992;42:829–31.
30. Nichols TW Jr. Alpha-lipoic acid: biological effects and clinical implications.
Altern Med Rev 1997;2:177–83
32.
Stojanovic S, Sprinz H, Brede O. Efficiency and mechanism of the antioxidant
action of trans-resveratrol and its analogues in the radical liposome oxidation.
Research Unit Time-Resolved Spectroscopy, University of Leipzig, Permoserstrasse
15, D-04318 Leipzig, Germany. Arch Biochem Biophys. 2001 Jul 1;391(1):79-89.
Literatura
- Chemistry and Applications of Green Tea by Takehiko Yamamoto, Lekh Raj Juneja, Djoing-Chi Chu, Mujo Kim, L.R. Juneja, D.C. Chu, M. Kim
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